The Histone Modification Code in the Pathogenesis of Autoimmune Diseases

Figure 2

(a) Histone modifications, including methylation, acetylation, ubiquitination, phosphorylation, and sumoylation, have various biological functions, such as the regulation of chromatin states and gene transcription. (b) Lysine residues of histone tails are subject to monomethylation (me1), dimethylation (me2), or trimethylation (me3). (c) Arginine residues of histone tails are subject to monomethylation (me1), symmetrical dimethylation (me2s), or asymmetrical dimethylation (me2a).

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(b)

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