DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone

<div>Protein expression of iNOS, an inflammation-pathway-downstream effector, was only induced by IL-1<i>β</i> or TNF-<i>α</i> not by DAMPs. Bovine (a) or human (b) articular chondrocytes were treated with DAMPs or cytokines or Fn-f or in combination for 24 hrs. Cells were then lyzed, and the lysates were examined for expression of iNOS with Western blotting.</div>

Mediators of Inflammation

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Figure 5

Figure 5: DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone 