Lysophosphatidic Acid Triggers Apoptosis in HeLa Cells through the Upregulation of Tumor Necrosis Factor Receptor Superfamily Member 21

Figure 3

LPA-induced DR6 upregulation is mediated by LPA receptors 1/3 (LPAR1/3). (a and b), LPA1, LPA2, and LPA3 mRNA and protein are all expressed in HeLa cells, as indicated by PCR and Western blot, respectively. . (c) LPA1/3 antagonist Ki16425 (3 μM) attenuated the DR6 upregulation induced by LPA. . (d) The bar graphs are statistical analysis of DR6 expression. Data presented are mean ± SD from 4 independent experiments, with untreated controls set as 1. versus control; versus LPA.

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