Epac1 Blocks NLRP3 Inflammasome to Reduce IL-1β in Retinal Endothelial Cells and Mouse Retinal Vasculature

Figure 2

Epac1 reduces formation of the NLRP3 inflammasome and the cleavage of caspase-1. Western blot data from retinal lysates from Epac1 floxed and Epac1 Cre-Lox mice for NLRP3 (a) and cleaved caspase-1 (b). versus Epac1 floxed. . Data are mean ± SEM.

(a)

(b)