Stigmasterol Modulates Allergic Airway Inflammation in Guinea Pig Model of Ovalbumin-Induced Asthma

Figure 3

Effect of stigmasterol on BALF oxidative stress markers. Guinea pigs were sensitized and challenged with ovalbumin as described in the methods. Animals received either saline, dexamethasone, or stigmasterol 1 h prior to each challenge. Naïve controls received normal saline only. Bronchoalveolar fluid was collected by aspiration 24 h after the last ovalbumin challenge and centrifuged for 1000 rpm for 10 min. The supernatant was analyzed quantitatively for level of malondialdehyde (a), reduced glutathione (b), superoxide dismutase (c), and catalase (d). Data is expressed as mean concentration/mg protein ± SEM (). , , and as compared to the saline-treated group, and ^### as compared to the naïve group using one-way ANOVA followed by Dunnet’s post hoc test.

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