A Role for CD154, the CD40 Ligand, in Granulomatous Inflammation
Immunohistochemical staining of monocyte/macrophage cells and cytokine/chemokine expression in WT and CD154KO mice after CCl4 injections. (a) Representative liver tissue sections from WT and CD154KO mice stained with the anti-F4/80 antigen monoclonal antibody after 3 and 9 CCl4 injections (inj.). Top panels, low magnifications (scale bar 500 μm); bottom panels, high magnifications (scale bar 100 μm) ( for each condition in each group of mice). Relative liver levels of F4/80 (b), IL-4 (c), MCP-1 (d), IL-6 (e), and MIP-2 (f) mRNA (fold arbitrary units), in WT and CD154KO mice at time 0 and after 3 and 9 CCl4 injections (inj.) (mean ± SD, , ).