Indirubin Treatment of Lipopolysaccharide-Induced Mastitis in a Mouse Model and Activity in Mouse Mammary Epithelial Cells

Figure 1

Effect of indirubin on the macroscopic pathology and histological changes in LPS-induced mouse mastitis. Representative macroscopic (a–f) and histological (g–l) changes in mammary glands from the (a, g) control, (b, h) LPS, (c, i) LPS + indirubin (25 μM), (d, j) LPS + indirubin (50 μM), (e, k) LPS + indirubin (100 μM), and (f, l) Dex groups (histological changes observed at 100x magnification; the insets are 400x magnification). (m) Major mammary score ( versus control group; versus LPS group).

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