Enhanced Expression of IL-18 and IL-18BP in Plasma of Patients with Eczema: Altered Expression of IL-18BP and IL-18 Receptor on Mast Cells

Figure 4

Flow cytometry analysis of the expression of IL-18 binding protein (BP) in dispersed skin mast cells of mice. (a) FMO for IL-18BP; (b), (d), and (f) show percentage of IL-18BP+ mast cells in skin of healthy mice (HM) and in normal or inflammatory skin of eczema mice treated with normal saline (NS), respectively. (c), (e), and (g) show percentage of IL-18BP+ mast cells in skin of healthy mice (HM) and in normal or inflammatory skin of eczema mice treated with IL-18, respectively. (h) represents median percentage values of mast cells in mouse skin. (i) shows representative flow cytometric figures of mean fluorescence intensity (MFI) of IL-18BP+ mast cell. (j) demonstrates changes in MFI of IL-18BP+ mast cell. Data shown are the median (range) value from 6 different mice. in comparison with NS group (paired Mann–Whitney U test). ^‡ compared with HM NS group.