Effects of Secreted Mast Cell Mediators on Retinal Pigment Epithelial Cells: Focus on Mast Cell Tryptase

Figure 6

VEGF production by RPE cells simulated with mast cell mediators. ELISA revealed constitutive production of VEGF. RPE cells were incubated with or without tryptase, histamine, TNF-α, eotaxin, MIP-1α, or I-309 at various concentrations for 24 h. Tryptase enhanced VEGF production in a concentration-dependent manner, while the other mast cell mediators did not. Data are shown as the mean ± SEM of three independent experiments. , significantly different from the control.