Research Article

Expression Profiling of Long Noncoding RNA Splice Variants in Human Microvascular Endothelial Cells: Lipopolysaccharide Effects In Vitro

Table 4

Significant canonical pathways identified by Ingenuity Pathway Analysis (IPA) in HMECs after 3 h treatment with LPS.

Ingenuity canonical pathways−log( value)

Granulocyte adhesion and diapedesis4.1
Role of macrophages, fibroblasts, and endothelial cells in rheumatoid arthritis3.9
Agranulocyte adhesion and diapedesis3.7
Atherosclerosis signaling3.7
Glucocorticoid receptor signaling3.5
Role of IL-17A in arthritis3.5
Activation of IRF by cytosolic pattern recognition receptors3.5
Role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza3.3
IL-17 signaling3.2
Role of IL-17A in psoriasis3.2
Death receptor signaling3.1
HMGB1 signaling3.0
Hepatic fibrosis/hepatic stellate cell activation3.0
Differential regulation of cytokine production in macrophages and T helper cells by IL-17A and IL-17F2.9
TNFR2 signaling2.9
TREM1 signaling2.7
Differential regulation of cytokine production in intestinal epithelial cells by IL-17A and IL-17F2.7
Communication between innate and adaptive immune cells2.6
Acute-phase response signaling2.5
Role of cytokines in mediating communication between immune cells2.4
Role of IL-17F in allergic inflammatory airway diseases2.4
TNFR1 signaling2.4
Dendritic cell maturation2.2
IL-17A signaling in gastric cells2.1
IL-17A signaling in airway cells2.0
Inflammasome pathway2.0
Role of pattern recognition receptors in recognition of bacteria and viruses2.0
IL-6 signaling1.9
TWEAK signaling1.8
Systemic lupus erythematosus signaling1.8
CD40 signaling1.7
Hepatic cholestasis1.6
LXR/RXR activation1.6
Retinoic acid-mediated apoptosis signaling1.6
Lymphotoxin β receptor signaling1.6
IL-17A signaling in fibroblasts1.6
PPAR signaling1.6
Eicosanoid signaling1.6
Hematopoiesis from pluripotent stem cells1.5
Altered T cell and B cell signaling in rheumatoid arthritis1.4
Coagulation system1.3
B cell-activating factor signaling1.3
Role of osteoblasts, osteoclasts, and chondrocytes in rheumatoid arthritis1.3
Induction of apoptosis by HIV11.3
Cholecystokinin/gastrin-mediated signaling1.3
PI3K signaling in B lymphocytes1.3
Toll-like receptor signaling1.3