Research Article

Expression Profiling of Long Noncoding RNA Splice Variants in Human Microvascular Endothelial Cells: Lipopolysaccharide Effects In Vitro

Table 5

Significant canonical pathways identified by Ingenuity Pathway Analysis (IPA) in HMECs after 24 h treatment with LPS.

Ingenuity canonical pathways−log( value)

Role of IL-17F in allergic inflammatory airway diseases7.1
Role of IL-17A in arthritis5.7
Agranulocyte adhesion and diapedesis5.7
Granulocyte adhesion and diapedesis5.4
Role of IL-17A in psoriasis4.9
Role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza4.6
Role of macrophages, fibroblasts, and endothelial cells in rheumatoid arthritis4.6
Communication between innate and adaptive immune cells4.5
Differential regulation of cytokine production in macrophages and T helper cells by IL-17A and IL-17F4.3
HMGB1 signaling4.2
Differential regulation of cytokine production in intestinal epithelial cells by IL-17A and IL-17F4.0
Role of cytokines in mediating communication between immune cells3.5
Glucocorticoid receptor signaling3.5
Atherosclerosis signaling3.4
Retinol biosynthesis3.4
Hepatic fibrosis/hepatic stellate cell activation3.0
Acute-phase response signaling2.9
IL-17 signaling2.8
Graft-versus-host disease signaling2.8
IL-17A signaling in fibroblasts2.6
Hematopoiesis from pluripotent stem cells2.5
Dendritic cell maturation2.5
TREM1 signaling2.4
IL-17A signaling in gastric cells2.3
IL-17A signaling in airway cells2.3
The visual cycle2.3
Role of pattern recognition receptors in recognition of bacteria and viruses2.2
Altered T cell and B cell signaling in rheumatoid arthritis2.2
Role of osteoblasts, osteoclasts, and chondrocytes in rheumatoid arthritis2.0
Systemic lupus erythematosus signaling2.0
Activation of IRF by cytosolic pattern recognition receptors1.9
Role of MAPK signaling in the pathogenesis of influenza1.9
Hepatic cholestasis1.9
LXR/RXR activation1.9
Retinoate biosynthesis I1.8
Bile acid biosynthesis, neutral pathway1.8
Methylglyoxal degradation III1.8
Airway pathology in chronic obstructive pulmonary disease1.8
IL-6 signaling1.6
Crosstalk between dendritic cells and natural killer cells1.5
Triacylglycerol degradation1.5
Induction of apoptosis by HIV11.5
Cholecystokinin/gastrin-mediated signaling1.5
OX40 signaling pathway1.5
Chemokine signaling1.4
Role of tissue factor in cancer1.4
Antigen presentation pathway1.3
PPAR signaling1.3