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Mediators of Inflammation
Volume 2017, Article ID 3480234, 8 pages
Research Article

Serum Cytokeratin 18 M30 Levels in Chronic Hepatitis B Reflect Both Phase and Histological Activities of Disease

1Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland
2Department of Physiology, Medical University of Bialystok, Bialystok, Poland
3Department of Infectious Diseases and Hepatology in Bytom, Medical University of Silesia, Katowice, Poland

Correspondence should be addressed to Magdalena Świderska; lp.ude.bmu@aksrediws.aneladgam

Received 13 April 2017; Revised 2 July 2017; Accepted 9 July 2017; Published 30 July 2017

Academic Editor: Partha Mukhopadhyay

Copyright © 2017 Magdalena Świderska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Chronic hepatitis B has highly a dynamic course with significant fluctuations of HBV-DNA and ALT impeding assessment of disease activity. New biomarkers of inflammatory versus noninflammatory stages of HBV infection are urgently needed. Cytokeratin 18 epitope M30 (M30 CK-18) is a sensitive marker of cell death. We aimed to investigate an association between serum M30 CK-18 and histological activity and phase of HBV infection. 150 Caucasian patients with HBV-infection were included in the study. Serum M30 CK-18 levels reflected phase of disease, being significantly higher in both HBeAg(+) and HBeAg(−) hepatitis B in comparison to HBsAg(+) carrier groups. The highest serum M30 CK-18 levels were observed in subjects with the most advanced stages of HBV. Moreover, its serum concentrations correlated with both inflammatory activity and fibrosis advancement (ANOVA ). Importantly, serum M30 CK-18 levels were able to discriminate patients with mild versus moderate-advanced fibrosis (AUC: 0.86) and mild versus active liver inflammation (AUC: 0.79). M30 CK-18 serum concentration has good sensitivity and specificity in discriminating mild versus moderate/severe fibrosis and inflammation even in patients with normal ALT activity. This study suggests M30 CK-18 as a potential noninvasive marker of disease activity and also a marker of phase of persistent HBV infection.