Serum Cytokeratin 18 M30 Levels in Chronic Hepatitis B Reflect Both Phase and Histological Activities of Disease

Table 1

Characteristics of studied population (median, IQR). Significant differences between consecutive phases by Kruskall-Wallis ANOVA were marked as follows: value < 0.05 and .

	Total group ()	HBeAg(+) hepatitis ()	Low replicative carriers ()	High replicative carriers ()	HBeAg(−) hepatitis ()
Gender, M; n (%)	86 (57)	7 (70)	19 (40)	15 (53)	45 (69)
Age, years	33 (23–42)	39 (24–53)	34 (25–45)	30 (23–39)	32 (23–40)
HBeAg(+), n (%)	10 (7)	10 (100)	—	—	—
HBV-DNA log10 IU/mL	4.1 (2.5–5.1)	5.1 (4.7-8.0)	2.3 (2.3–2.4)	3.9 (3.5–4.3)	5.0 (4.4-5.7)
HBsAg log10 IU/mL	4.2 (3.6–4.6)	4.3 (3.9–5.0)	4.1 (3.3-4.6)	4.1 (3.6–4.6)	4.3 (4.1–4.6)
ALT, IU/mL	30 (22–44)	70 (43–88)	23 (18–31)	27 (23–33)	36 (26–73)
GGT, IU/mL	18 (11–32)	28 (22–41)	13 (10–20)	18 (13–21)	25 (12–47)
Platelets, 10^9/L	190 (157–220)	122 (110–154)	189 (155–219)	196 (171–224)	193 (166–219)
Prothrombin ratio, %	100 (90–107)	89 (82–98)	103 (96–110)	102 (92–110)	96 (89–107)