Research Article
Serum Cytokeratin 18 M30 Levels in Chronic Hepatitis B Reflect Both Phase and Histological Activities of Disease
Table 3
Serum M30 CK-18 (median ± IQR) concentrations with regard to inflammatory activity and fibrosis stage in liver biopsy.
| | Inflammatory activity | Fibrosis advancement | | G0–G2 () | G3–G4 () | S0–S1 () | S2–S4 () |
| | Age, years | 31 (25–38) | 39 (21–59) | 31 (25–38) | 39 (23–51) | | HBV-DNA, log10 IU/mL | 4.46 (3.6–5.28) | 4.00 (3.23–6.19) | 4.46 (3.61–5.27) | 4.00 (3.18–7.39) | | HBsAg, log10 IU/mL | 4.25 (3.94–4.59) | 4.14 (3.95–4.77) | 4.27 (3.99–4.61) | 4.11 (3.95–4.57) | | CK-18, U/L | 124 (74–225) | 466 (197–1268) | 120 (74–201) | 521 (272–1268) | | ALT, IU/mL | 34 (26–52) | 73 (30–109) | 34 (27–51) | 73 (36–109) | | GGT, IU/mL | 19 (12–32) | 38 (28–114) | 19 (12–32) | 38 (28–114) | | Platelets, 109/L | 198 (170–219) | 127 (107–201) | 201 (170–219) | 126 (107–164) |
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