Inhibiting Interleukin 17 Can Ameliorate the Demyelination Caused by A. cantonensis via iNOS Inhibition

Figure 1

A. cantonensis infection caused demyelination in infected mice. (a) Transmission electronic image of the optic nerve at 0 d, 7 d, 14 d, and 21 d after A. cantonensis infection. Prominent demyelination (the black arrows point) can be observed in 14 d and 21 d. Scale bar = 1 μm. (b) The MBP protein expression of the brain via western blotting at 0, 7, 14, and 21 days after A. cantonensis infection. (c) The relative ration of MBP protein expression (β-actin was as the internal reference). These expressions decreased as time extended and had obvious difference with the control in 21 d of infection. Numerical results are presented as mean ± SEM. animals per group, at least three fields were analyzed per section in at least two sections not next to each other per animal. represents statistically significant values when compared with the normal control ().

(a)

(b)

(c)