Inhibiting Interleukin 17 Can Ameliorate the Demyelination Caused by A. cantonensis via iNOS Inhibition

Figure 3

IL-17A inhibition can ameliorate the demyelination caused by A. cantonensis. (a) TEM picture of the optic nerve in the normal group, 21 d A. cantonensis infection group, normal mice with IL-17A antibody group, and 21 d A. cantonensis infection with IL-17A antibody group. IL-17A inhibition can restore the demyelination caused by A. cantonensis to the normal level. Scale bar = 1 μm. (b) The MBP protein expression of the brain via western blotting in the normal group, 21 d A. cantonensis infection group, normal mice with IL-17A antibody group, and 21 d A. cantonensis infection with IL-17A antibody group. (c) The semiquantification of MBP protein expression via western blotting in different groups (β-actin as the internal reference). IL-17A inhibition had no effect on MBP expression of the brain in the normal group but increased MBP expression in the 21 d A. cantonensis infection group. animals per group, at least three fields were analyzed per section in at least two nonadjacent sections per animal. represents statistically significant values when compared with normal control ().

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