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Mediators of Inflammation
Volume 2017 (2017), Article ID 3718451, 11 pages
Research Article

HBV Viral Load and Liver Enzyme Levels May Be Associated with the Wild MBL2 AA Genotype

1Laboratory of Virology, Institute of Biological Sciences, Universidade Federal do Pará (UFPA), Guamá, 66075-110 Belém, PA, Brazil
2João de Barros Barreto University Hospital, Federal University of Pará (Universidade Federal do Pará (UFPA)), Guamá, 66073-000 Belém, PA, Brazil
3School of Medicine, Institute of Health Sciences, Universidade Federal do Pará (UFPA), Umarizal, 66055-380 Belém, PA, Brazil
4Hepatology Outpatient Service, Santa Casa de Misericórdia do Pará, Umarizal, 66055-380 Belém, PA, Brazil

Correspondence should be addressed to Antonio Carlos Rosário Vallinoto

Received 1 December 2016; Revised 24 January 2017; Accepted 6 February 2017; Published 12 March 2017

Academic Editor: Magdalena Klink

Copyright © 2017 Tuane Carolina Ferreira Moura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present study investigated the frequencies of rs1800450 (MBLB, G>A), rs1800451 (MBLC, G>A), and rs5030737 (MBLD, C>T) polymorphisms in exon 1 of the MBL2 gene among patients with chronic viral hepatitis. Blood samples from patients infected with hepatitis B virus (HBV; ), hepatitis C virus (HCV; ), and a noninfected control group () were investigated. The presence of polymorphisms was detected using a real-time polymerase chain reaction to correlate with liver disease pathogenesis and fibrosis staging according to the Metavir classification. The genotypic and allelic frequencies showed no significant differences between the groups, but patients with active HBV and the wild AA genotype presented a positive correlation between increased transaminase and HBV DNA levels and the presence of mild to moderate fibrosis. Patients with HCV and the wild AA genotype presented mild inflammation and higher HCV RNA levels, although the same association was not observed for the fibrosis scores. The results suggest that the mutations in exon 1 of the MBL2 gene do not contribute directly to the clinical and laboratory features of HCV and HBV infections, but further studies should be performed to confirm whether the wild AA genotype has indirect effect on disease progression.