HBV Viral Load and Liver Enzyme Levels May Be Associated with the Wild MBL2 AA Genotype
Table 3
Correlation between polymorphisms in exon 1 of the MBL2 gene with the inflammatory activity and fibrosis score in samples from patients infected with HBV and HCV.
Genetic profile infection
Inflammatory activity
Fibrosis score
0 to 1
2 to 3
p
0 to 2
3 to 4
p
(%)
(%)
(%)
(%)
HBV
AA
12 (52.2)
02 (50.0)
0.4286
13 (54.2)
09 (56.2)
0.3424
AO
10 (43.5)
01 (25.0)
09 (37.5)
07 (43.8)
OO
01 (04.3)
01 (25.0)
02 (08.3)
00 (00.0)
A
0.739
0.625
0.3896
0.729
0.781
0.3996
O
0.261
0.375
0.271
0.219
AA
12 (52.2)
02 (50.0)
0.6733
13 (54.2)
09 (56.2)
0.5778
AO + OO
11 (47.8)
02 (50.0)
11 (55.8)
07 (53.8)
HCV
AA
23 (63.9)
15 (60.0)
0.2833
26 (61.9)
17 (58.6)
0.2966
AO
11 (30.5)
10 (40.0)
14 (33.3)
12 (41.4)
OO
02 (05.6)
00 (00.0)
02 (04.8)
00 (00.0)
A
0.792
0.800
0.5432
0.786
0.793
0.5439
O
0.208
0.200
0.214
0.207
AA
23 (63.9)
15 (60.0)
0.4826
26 (61.9)
17 (58.6)
0.4862
AO + OO
13 (36.1)
10 (40.0)
16 (38.1)
12 (41.4)
-test and Fisher’s exact test. HBV: hepatitis B virus and HCV: hepatitis C virus. Inflammatory activity (0 to 1: no inflammation and mild levels and 2 to 3: moderate to high levels); fibrosis score (0 to 2: mild and moderate and 3 to 4: severe and cirrhosis).
