Cynanchum wilfordii Polysaccharides Suppress Dextran Sulfate Sodium-Induced Acute Colitis in Mice and the Production of Inflammatory Mediators from Macrophages

Figure 3

Effects of HMFO on serum levels and immunohistochemical staining for proinflammatory cytokines. (a) TNF-α production in mouse sera on day 10. (b) IL-6 production in mouse sera on day 10. Immunohistochemical staining of TNF-α (c) and IL-6 (d) in colonic tissue (×40, scale bar = 50 μm). Brown staining indicates TNF-α (c) and IL-6 (d) positivity, respectively. Values with different letters are significantly different (). 5-ASA, 5-aminosalicylic acid (100 mg/kg); DSS, dextran sulfate sodium; HMFO, polysaccharides of Cynanchum wilfordii (100 or 200 mg/kg).

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