Mediators of Inflammation / 2017 / Article / Tab 3

Research Article

Gene Expression, Oxidative Stress, and Senescence of Primary Coronary Endothelial Cells Exposed to Postprandial Serum of Healthy Adult and Elderly Volunteers after Oven-Cooked Meat Meals

Table 3

Enriched pathway-based sets identified by ConsensusPathDB.

Pathway nameSet sizeCandidates contained value valuePathway source

Chemical carcinogenesis8218 (22.0%)0.0008420.203KEGG
MAPK signaling pathway16830 (17.9%)0.0008890.203WikiPathways
Xenobiotics metabolism5313 (25.5%)0.001010.203EHMN
Drug metabolism4612 (26.1%)0.001260.203KEGG
TNFR1-induced NF-κB signaling pathway268 (30.8%)0.002630.232Reactome
Oxidative stress-induced senescence12923 (18%)0.00310.242Reactome
Ubiquitin-mediated proteolysis13724 (17.5%)0.003590.243KEGG
Cellular senescence19230 (15.7%)0.006540.318Reactome
Oxidative stress308 (26.7)0.006930.318WikiPathways
The fatty acid cycling model53 (60%)0.008120.318Reactome
TNF signaling379 (24.3%)0.008160.318Reactome

1243 genes (59.7%) from the input list (2877 genes) are present in at least one pathway.

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