15-Deoxy-Δ^12,14-prostaglandin J₂ Exerts Antioxidant Effects While Exacerbating Inflammation in Mice Subjected to Ureteral Obstruction

Figure 4

15d-PGJ₂ receptor expression is increased in response to UUO. mRNA was purified from kidney cortical tissue and analyzed using qPCR. (a) Dp1 mRNA levels in response to UUO. (b) Crth2 mRNA levels in response to UUO. (c) Pparγ mRNA levels in response to UUO. 15d-PGJ₂ was administered at a low (0.5 mg/kg/day) and a high (1 mg/kg/day) dose as depicted in each graph. Data represents mean ± SEM. versus that in sham, using ANOVA and Bonferroni’s post hoc tests (, sham; , 3-day UUO groups). UUO, unilateral ureteral obstruction.

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