15-Deoxy-Δ^12,14-prostaglandin J₂ Exerts Antioxidant Effects While Exacerbating Inflammation in Mice Subjected to Ureteral Obstruction

Table 2

Effect of 15d-PGJ2 on body weight, kidney weight, and functional plasma parameters.

	Sham	UUO	UUO + low 15d-PGJ2	UUO + high 15d-PGJ2
Body weight, g	21.6 ± 0.8	19.3 ± 1.0	20.0 ± 0.5	19.8 ± 0.5
Obstructed KW, mg/20 g BW	113.3 ± 4.7	184.8 ± 3.1^#	176.7 ± 3.1	180.9 ± 3.2
Plasma creatinine, μmol/l	7.4 ± 0.7	9.3 ± 0.9	10.5 ± 0.9	8.3 ± 0.4
BUN, mmol/l	8.9 ± 0.3	8.6 ± 0.3	9.1 ± 0.2	11.2 ± 0.6

Biochemical values. Mice were subjected to UUO for 3 days (UUO) and treated with 15d-PGJ2 at a low dose (0.5 mg/kg/day) and a high dose (1 mg/kg/day). At the time of sacrifice, a blood sample was taken from the left ventricle. Body weight and obstructed kidney weight were measured. Plasma creatinine and BUN were measured using Roche Cobas 6000 analyzer (Roche Diagnostics, Hvidovre, Denmark). Values are means ± SEM, . versus that in sham. versus that in UUO. 15d-PGJ2: 15-deoxy-Δ^12,14-prostaglandin J₂; BW: body weight; KW: kidney weight; BUN: blood urea nitrogen.