The Protective Effect of Cordycepin on D-Galactosamine/Lipopolysaccharide-Induced Acute Liver Injury

Figure 1

Cordycepin protects against hepatic damage induced by GalN/LPS. C57BL/6J mice were orally administrated with 50 mg/kg or 200 mg/kg cordycepin for 3 consecutive weeks, and GalN (700 mg/kg)/LPS (15 μg/kg) was injected at 1 h before the last gavage. (a) The mortality rates were observed at various time points within 12 h after injected with a lethal dose of GalN/LPS (n = 10). The blood and liver tissues were harvested at 5 h after GalN/LPS treatment. (b and c) Then serum ALT, AST, and HMGB1 levels were assayed (n = 10). Represent visibly different damaged livers (d) and H&E staining analysis of liver sections (e) were shown. Upper scale bars: 100 μm. Under scale bars: 50 μm. Percent of necrotic area was calculated (n = 5). Each value is mean ± SEM. , , .

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