Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2017, Article ID 3958069, 14 pages
https://doi.org/10.1155/2017/3958069
Review Article

Dual Roles of IL-27 in Cancer Biology and Immunotherapy

Laboratory of Biotherapy, IRCCS AOU San Martino-IST, Istituto Nazionale per la Ricerca sul Cancro, 16132 Genoa, Italy

Correspondence should be addressed to Silvano Ferrini; ti.orebil@inirref.onavlis

Received 31 October 2016; Revised 23 December 2016; Accepted 12 January 2017; Published 1 February 2017

Academic Editor: Dmitri V. Krysko

Copyright © 2017 Marina Fabbi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [15 citations]

The following is the list of published articles that have cited the current article.

  • Sitang Maknitikul, Natthanej Luplertlop, Georges E. R. Grau, and Sumate Ampawong, “Dysregulation of pulmonary endothelial protein C receptor and thrombomodulin in severe falciparum malaria-associated ARDS relevant to hemozoin,” Plos One, vol. 12, no. 7, pp. e0181674, 2017. View at Publisher · View at Google Scholar
  • Elena Chaves-Pozo, Yulema Valero, Anna Esteve-Codina, Jèssica Gómez-Garrido, Marc Dabad, Tyler Alioto, José Meseguer, M. Ángeles Esteban, and Alberto Cuesta, “Innate Cell-Mediated Cytotoxic Activity of European Sea Bass Leucocytes Against Nodavirus-Infected Cells: A Functional and RNA-seq Study,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Grazia Carbotti, Amin Reza Nikpoor, Paola Vacca, Rosaria Gangemi, Chiara Giordano, Francesco Campelli, Silvano Ferrini, and Marina Fabbi, “IL-27 mediates HLA class I up-regulation, which can be inhibited by the IL-6 pathway, in HLA-deficient Small Cell Lung Cancer cells,” Journal of Experimental & Clinical Cancer Research, vol. 36, no. 1, 2017. View at Publisher · View at Google Scholar
  • Zixi Hu, Cui Li, Wei Yang, Fengzhen Mo, Yongxiang Zhao, Xiaoling Lu, Yiwei Wang, Xue Ouyang, and Xiaomei Yang, “The research progress of artificial antigen presenting cells,” Journal of Nanoscience and Nanotechnology, vol. 17, no. 12, pp. 8640–8653, 2017. View at Publisher · View at Google Scholar
  • Simon A. Jones, and Brendan J. Jenkins, “Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer,” Nature Reviews Immunology, 2018. View at Publisher · View at Google Scholar
  • Catherine Rolvering, Andreas D. Zimmer, Aurélien Ginolhac, Christiane Margue, Mélanie Kirchmeyer, Florence Servais, Heike M. Hermanns, Sabine Hergovits, Petr V. Nazarov, Nathalie Nicot, Stephanie Kreis, Serge Haan, Iris Behrmann, and Claude Haan, “The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by α-PD-L1 or α-IL6 antibodies,” Journal of Leukocyte Biology, 2018. View at Publisher · View at Google Scholar
  • Hiroshi Nakashima, Ichiro Nakano, David A. Reardon, Vijay Kuchroo, Antonio Chiocca, Kazue Kasai, William F. Goins, Imran Shaikh, Ana C. Anderson, Tran Nguyen, Carmela Passaro, Hirotaka Ito, Ronald Erdelyi, and Reiko Nishihara, “Toxicity and efficacy of a novel gadd34-expressing oncolytic hsv-1 for the treatment of experimental glioblastoma,” Clinical Cancer Research, vol. 24, no. 11, pp. 2574–2584, 2018. View at Publisher · View at Google Scholar
  • Todd Bartkowiak, David S. Hong, Michael A. Curran, Ashvin R. Jaiswal, Matthew J. Reilley, Manu M. Sebastian, Casey R. Ager, Renee Chin, Chao-Hsien Chen, Pratha Budhani, and Midan Ai, “Activation of 4-1BB on liver myeloid cells triggers hepatitis via an interleukin-27–dependent pathway,” Clinical Cancer Research, vol. 24, no. 5, pp. 1138–1151, 2018. View at Publisher · View at Google Scholar
  • Mehdi Ghahartars, Shiva Najafzadeh, Shabnam Abtahi, Mohammad Javad Fattahi, and Abbas Ghaderi, “Investigation of Interleukin-27 in the Sera of Nonmelanoma Skin Cancer Patients,” Dermatology Research and Practice, vol. 2018, pp. 1–5, 2018. View at Publisher · View at Google Scholar
  • Maria Lampinen, Johan Vessby, Annika Fredricsson, Alkwin Wanders, Fredrik Rorsman, and Marie Carlson, “High Serum sCD40 and a Distinct Colonic T Cell Profile in Ulcerative Colitis Associated With Primary Sclerosing Cholangitis,” Journal of Crohn's and Colitis, 2018. View at Publisher · View at Google Scholar
  • Piotr Kopiński, Ewelina Wȩdrowska, Tomasz Senderek, Adriana Rozy, Tomasz Wandtke, Andrzej Dyczek, Grzegorz Przybylski, and Joanna Chorostowska-Wynimko, “Increased levels of interleukin 27 in patients with early clinical stages of non-small cell lung cancer,” Polish Archives of Internal Medicine, vol. 128, no. 2, pp. 105–114, 2018. View at Publisher · View at Google Scholar
  • Jean-Charles Ryff, and Sidney Pestka, “Interferons and Interleukins,” Pharmaceutical Biotechnology, pp. 619–643, 2019. View at Publisher · View at Google Scholar
  • Olena Kourko, Robin Smyth, Daniela Cino, Kyle Seaver, Carlene Petes, So Young Eo, Sam Basta, and Katrina Gee, “Poly(I:C)-Mediated Death of Human Prostate Cancer Cell Lines Is Induced by Interleukin-27 Treatment,” Journal of Interferon & Cytokine Research, 2019. View at Publisher · View at Google Scholar
  • Sergej Tomić, Bojan Joksimović, Marina Bekić, Miloš Vasiljević, Marijana Milanović, Miodrag Čolić, and Dragana Vučević, “Prostaglanin-E2 Potentiates the Suppressive Functions of Human Mononuclear Myeloid-Derived Suppressor Cells and Increases Their Capacity to Expand IL-10-Producing Regulatory T Cell Subsets,” Frontiers in Immunology, vol. 10, 2019. View at Publisher · View at Google Scholar
  • Qianyu Guo, Fan Huang, Christophe Goncalves, Sonia V. del Rincón, and Wilson H. Miller, “Translation of cancer immunotherapy from the bench to the bedside,” 2019. View at Publisher · View at Google Scholar