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Mediators of Inflammation
Volume 2017, Article ID 4123694, 6 pages
Review Article

Mediators of Inflammation and Angiogenesis in Chronic Spontaneous Urticaria: Are They Potential Biomarkers of the Disease?

1Clinical Immunology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
2Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School and National Cancer Institute “Giovanni Paolo II”, Bari, Italy

Correspondence should be addressed to Ilaria Puxeddu; ti.oohay@pirali

Received 19 May 2017; Accepted 7 August 2017; Published 5 September 2017

Academic Editor: Anna Balato

Copyright © 2017 Ilaria Puxeddu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In chronic spontaneous urticaria (CSU), different pathophysiological mechanisms, potentially responsible for the development of the disease, have been recently described. It is likely that the activation of skin mast cells with consequent release of histamine and other proinflammatory mediators is responsible for vasodilation in the lesional skin of CSU. However, the underlying causes of mast cell activation in the disease are largely unknown and remain to be identified. Thus, in this review, we discuss new insights in the pathogenesis of CSU, focusing on inflammation and angiogenesis. The understanding of these mechanisms will enable the identification of biomarkers useful for the diagnosis, follow-up, and management of CSU and will allow the development of novel, more specific, and patient-tailored therapies.