Mediators of Inflammation
Volume 2017 (2017), Article ID 4123694, 6 pages
https://doi.org/10.1155/2017/4123694
Mediators of Inflammation and Angiogenesis in Chronic Spontaneous Urticaria: Are They Potential Biomarkers of the Disease?
1Clinical Immunology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
2Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School and National Cancer Institute “Giovanni Paolo II”, Bari, Italy
Correspondence should be addressed to Ilaria Puxeddu; ti.oohay@pirali
Received 19 May 2017; Accepted 7 August 2017; Published 5 September 2017
Academic Editor: Anna Balato
Copyright © 2017 Ilaria Puxeddu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- T. Zuberbier, W. Aberer, R. Asero et al., “The EAACI/GA2LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update,” Allergy, vol. 69, pp. 868–887, 2014. View at Publisher · View at Google Scholar · View at Scopus
- I. Puxeddu, A. M. Piliponsky, I. Bachelet, and F. Levi-Schaffer, “Mast cells in allergy and beyond,” International Journal Biochemistry Cell Biolology, vol. 35, no. 12, pp. 1601–1607, 2003. View at Publisher · View at Google Scholar · View at Scopus
- A. P. Kaplan and M. Greave, “Pathogenesis of chronic urticaria,” Clinical Experimental Allergy, vol. 39, pp. 777–787, 2009. View at Publisher · View at Google Scholar · View at Scopus
- S. Altrichter, H. J. Peter, D. Pisarevskaja, M. Metz, P. Martus, and M. Maurer, “IgE mediated auto-allergy against thyroid peroxidase - a novel pathomechanism of chronic spontaneous urticaria?” PLoS One, vol. 6, article e14794, 2011. View at Publisher · View at Google Scholar · View at Scopus
- M. Maurer, G. A. Vena, and N. Cassano, “Current and future therapies for treating chronic spontaneous urticaria,” Expert Opinion Pharmacotherapy, vol. 17, no. 8, pp. 1131–1139, 2016. View at Publisher · View at Google Scholar · View at Scopus
- E. Kocatürk, M. Maurer, M. Metz, and C. Grattan, “Looking forward to new targeted treatments for chronic spontaneous urticaria,” Clinical Translational Allergy, vol. 7, p. 1, 2017. View at Publisher · View at Google Scholar
- Y. Xu and G. Chen, “Mast cell and autoimmune diseases,” Mediators of Inflammation, vol. 2015, Article ID 246126, 8 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
- C. E. Grattan, G. Dawn, S. Gibbs, and D. M. Francis, “Blood basophil numbers in chronic ordinary urticaria and healthy controls: diurnal variation, influence of loratadine and prednisolone and relationship to disease activity,” Clinical Experimental Allergy, vol. 33, pp. 337–341, 2003. View at Publisher · View at Google Scholar · View at Scopus
- R. Sabroe, D. Francis, and R. Barr, “Anti-Fc(episilon) RI auto antibodies and basophil histamine releasability in chronic idiopathic urticaria,” Journal Allergy Clinical Immunolology, vol. 102, pp. 651–658, 1998. View at Publisher · View at Google Scholar
- E. Luquin, A. Kaplan, and M. Ferrer, “Increased responsiveness of basophils of patients with chronic urticaria to sera but hypo-responsiveness to other stimuli,” Clinical Experimental Allergy, vol. 35, pp. 456–460, 2005. View at Publisher · View at Google Scholar · View at Scopus
- B. M. Vonakis, K. Vasagar, S. P. Gibbons Jr. et al., “Basophil Fcepsilon RI histamine release parallels expression of Src-homology 2-containing inositol phosphatases in chronic idiopathic urticaria,” Journal Allergy Clinical Immunology, vol. 119, pp. 441–448, 2007. View at Publisher · View at Google Scholar · View at Scopus
- S. Ying, Y. Kikuchi, Q. Meng, A. B. Kay, and A. P. Kaplan, “TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: comparison with the allergen-induced late-phase cutaneous reaction,” Journal Allergy Clinical Immunology, vol. 109, no. 4, pp. 694–700, 2002. View at Publisher · View at Google Scholar · View at Scopus
- R. A. Sabroe, E. Poon, G. E. Orchard et al., “Cutaneous inflammatory cell infiltrate in chronic idiopathic urticaria: comparison of patients with and without anti-FcepsilonRI or anti-IgE autoantibodies,” Journal Allergy Clinical Immunology, vol. 103, 3, Part 1, pp. 484–493, 1999. View at Publisher · View at Google Scholar
- M. Caproni, B. Giomi, W. Volpi et al., “Chronic idiopathic urticaria: infiltrating cells and related cytokines in autologous serum-induced wheals,” Clinical Immunology, vol. 114, no. 5, pp. 284–292, 2005. View at Publisher · View at Google Scholar · View at Scopus
- J. Elias, E. Boss, and A. P. Kaplan, “Studies of the cellular infiltrate of chronic idiopathic urticaria: prominence of T-lymphocytes, monocytes, and mast cells,” Journal Allergy Clinical Immunolology, vol. 78, no. 5, Part 1, pp. 914–918, 1986. View at Publisher · View at Google Scholar · View at Scopus
- A. B. Kay, P. Clark, M. Maurer, and S. Ying, “Elevations in T-helper-2-initiating cytokines (interleukin-33, interleukin-25 and thymic stromal lymphopoietin) in lesional skin from chronic spontaneous ('idiopathic') urticaria,” British Journal Dermatolology, vol. 172, no. 5, pp. 1294–1302, 2015. View at Publisher · View at Google Scholar · View at Scopus
- A. B. Kay, S. Ying, E. Ardelean et al., “Elevations in vascular markers and eosinophils in chronic spontaneous urticarial weals with low-level persistence in uninvolved skin,” British Journal Dermatolology, vol. 171, no. 3, pp. 505–511, 2014. View at Publisher · View at Google Scholar · View at Scopus
- A. Kasperska-Zajac, J. Sztylc, E. Machura, and G. Jop, “Plasma IL-6 concentration correlates with clinical disease activity and serum C-reactive protein concentration in chronic urticaria patients,” Clinical Experimental Allergy, vol. 41, no. 10, pp. 1386–1391, 2011. View at Publisher · View at Google Scholar · View at Scopus
- A. Kasperska-Zajac, “Acute-phase response in chronic urticaria,” Journal European Academy Dermatolology Venereololgy, vol. 26, no. 6, pp. 665–672, 2012. View at Publisher · View at Google Scholar · View at Scopus
- A. Tedeschi, M. Lorini, C. Suli, and R. Asero, “Serum interleukin-18 in patients with chronic ordinary urticaria: association with disease activity,” Clinical Experimental Dermatology, vol. 32, no. 5, pp. 568–570, 2007. View at Publisher · View at Google Scholar · View at Scopus
- E. Kurt, A. Aktas, K. Aksu et al., “Autologous serum skin test response in chronic spontaneous urticaria and respiratory diseases and its relationship with serum interleukin-18 level,” Archives Dermatology Research, vol. 303, no. 9, pp. 643–649, 2011. View at Publisher · View at Google Scholar · View at Scopus
- I. Puxeddu, P. Italiani, P. Giungato et al., “Free IL-18 and IL-33 cytokines in chronic spontaneous urticaria,” Cytokine, vol. 61, no. 3, pp. 741–743, 2013. View at Publisher · View at Google Scholar · View at Scopus
- P. Migliorini, C. Anzilotti, F. Pratesi et al., “Serum and urinary levels of IL-18 and its inhibitor IL-18BP in systemic lupus erythematosus,” European Cytokine Network, vol. 21, no. 4, pp. 264–271, 2010. View at Google Scholar
- M. A. Atwa, A. S. Emara, N. Youssef, and N. M. Bayoumy, “Serum concentration of IL-17, IL-23 and TNF-α among patients with chronic spontaneous urticaria: association with disease activity and autologous serum skin test,” Journal European Academy Dermatology Venereology, vol. 28, no. 4, pp. 469–474, 2014. View at Publisher · View at Google Scholar · View at Scopus
- Y. Bae, K. Izuhara, S. Ohta et al., “Periostin and interleukin-13 are independently related to chronic spontaneous urticaria,” Allergy Asthma Immunology Research, vol. 8, no. 5, pp. 457–460, 2016. View at Publisher · View at Google Scholar · View at Scopus
- A. Kaplan, “Inflammation in chronic urticaria is not limited to the consequences of mast cell (or basophil) degranulation,” Clinical Expermental Allergy, vol. 40, no. 6, pp. 834-835, 2010. View at Publisher · View at Google Scholar · View at Scopus
- A. Kasperska-Zajac, A. Grzanka, M. Misiolek, B. Mazur, and E. Machura, “Pentraxin-3 as a local inflammatory marker in chronic spontaneous urticaria,” Cytokine, vol. 76, no. 2, pp. 566–568, 2015. View at Publisher · View at Google Scholar · View at Scopus
- C. O. Bingham, “Immunomodulatory approaches to the management of chronic urticaria: an immune-mediated inflammatory disease,” Current Allergy Asthma Reports, vol. 8, no. 4, pp. 278–287, 2008. View at Publisher · View at Google Scholar · View at Scopus
- S. Jain, “Pathogenesis of chronic urticaria: an overview,” Dermatology Research Practice, vol. 2014, Article ID 674709, 10 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
- S. Pastore, F. Mascia, F. Mariotti, C. Dattilo, and G. Girolomoni, “Chemokine networks in inflammatory skin diseases,” European Journal Dermatology, vol. 14, pp. 203–208, 2004. View at Google Scholar
- M. L. Castellani, M. A. De Lutiis, E. Toniato et al., “Impact of RANTES, MCP-1 and IL-8 in mast cells,” Journal Biological Regulator Homeostatic Agents, vol. 24, no. 1, pp. 1–6, 2010. View at Google Scholar
- M. Caproni, W. Volpi, D. Macchia et al., “Infiltrating cells and related cytokines in lesional skin of patients with chronic idiopathic urticaria and positive autologous serum skin test,” Experimental Dermatology, vol. 12, no. 5, pp. 621–628, 2003. View at Google Scholar
- M. Sánchez-Borges, F. Caballero-Fonseca, A. Capriles-Hulett, L. González-Aveledo, and M. Maurer, “Factors linked to disease severity and time to remission in patients with chronic spontaneous urticaria,” Journal European Academy Dermatolology Venereololgy, vol. 31, no. 6, pp. 964–971, 2017. View at Publisher · View at Google Scholar
- Y. S. Baek, J. Jeon, J. H. Kim, and C. H. Oh, “Severity of acute and chronic urticaria correlates with D-dimer level, but not C-reactive protein or total IgE,” Clinical Experimental Dermatology, vol. 39, no. 7, pp. 795–800, 2014. View at Publisher · View at Google Scholar · View at Scopus
- H. K. Trinh, D. L. Pham, G. Y. Ban, H. Y. Lee, H. S. Park, and Y. M. Ye, “Altered systemic adipokines in patients with chronic urticaria,” International Archives Allergy Immunology, vol. 171, no. 2, pp. 102–110, 2016. View at Publisher · View at Google Scholar · View at Scopus
- Y. M. Ye, H. J. Jin, E. K. Hwang et al., “Co-existence of chronic urticaria and metabolic syndrome: clinical implications,” Acta Dermatology Venereology, vol. 93, no. 2, pp. 156–160, 2013. View at Publisher · View at Google Scholar · View at Scopus
- E. Toubi, A. Kessel, N. Avshovich et al., “Clinical and laboratory parameters in predicting chronic urticaria duration: a prospective study of 139 patients,” Allergy, vol. 59, no. 8, pp. 869–873, 2004. View at Publisher · View at Google Scholar · View at Scopus
- S. Vohra, N. L. Sharma, V. K. Mahajan, and V. Shanker, “Clinicoepidemiologic features of chronic urticaria in patients having positive versus negative autologous serum skin test: a study of 100 Indian patients,” Indian Journal Dermatology Venereology Leprology, vol. 77, no. 2, pp. 156–159, 2011. View at Publisher · View at Google Scholar · View at Scopus
- E. Kocatürk, M. Kavala, E. Kural, S. Sarıgul, and I. Zındancı, “Autologous serum skin test vs autologous plasma skin test in patients with chronic urticaria: evaluation of reproducibility, sensitivity and specificity and relationship with disease activity, quality of life and anti-thyroid antibodies,” European Journal Dermatology, vol. 21, no. 3, pp. 339–343, 2011. View at Publisher · View at Google Scholar · View at Scopus
- P. Staubach, K. Onnen, and A. Vonend, “Autologous whole blood injections to patients with chronic urticaria and a positive autologous serum skin test: a placebo-controlled trial,” Dermatology, vol. 212, no. 2, pp. 150–159, 2006. View at Publisher · View at Google Scholar · View at Scopus
- Y. M. Ye, J. W. Park, S. H. Kim et al., “Prognostic factors for chronic spontaneous urticaria: a 6-month prospective observational study,” Allergy Asthma Immunology Research, vol. 8, no. 2, pp. 115–123, 2016. View at Publisher · View at Google Scholar · View at Scopus
- D. Burger and M. T. Rhian, “Cellular biomarkers of endothelial health: microparticles, endothelial progenitor cells, and circulating endothelial cells,” Journal of the American Society of Hypertension, vol. 6, no. 2, pp. 85–99, 2012. View at Publisher · View at Google Scholar · View at Scopus
- I. Puxeddu, F. Panza, F. Pratesi et al., “CCL5/RANTES, sVCAM-1, and sICAM-1 in chronic spontaneous urticaria,” International Archives Allergy Immunology, vol. 162, no. 4, pp. 330–334, 2013. View at Publisher · View at Google Scholar · View at Scopus
- K. H. Lee, J. Y. Kim, D. S. Kang, Y. J. Choi, W. J. Lee, and J. Y. Ro, “Increased expression of endothelial cell adhesion molecules due to mediator release from human foreskin mast cells stimulated by autoantibodies in chronic urticaria sera,” Journal Investigative Dermatology, vol. 118, no. 4, pp. 658–663, 2002. View at Publisher · View at Google Scholar · View at Scopus
- R. Asero, A. Tedeschi, A. V. Marzano, and M. Cugno, “Chronic spontaneous urticaria: immune system, blood coagulation, and more,” Expert Review Clinical Immunology, vol. 12, no. 3, pp. 229–231, 2016. View at Publisher · View at Google Scholar · View at Scopus
- R. Asero, A. Tedeschi, R. Coppola et al., “Activation of the tissue factor pathway of blood coagulation in patients with chronic urticaria,” Journal Allergy Clinical Immunology, vol. 119, no. 3, pp. 705–710, 2007. View at Publisher · View at Google Scholar · View at Scopus
- A. Tedeschi, P. Kolkhir, R. Asero et al., “Chronic urticaria and coagulation: pathophysiological and clinical aspects,” Allergy, vol. 69, no. 6, pp. 683–691, 2014. View at Publisher · View at Google Scholar · View at Scopus
- R. Asero, A. V. Marzano, S. Ferrucci, and M. Cugno, “D-dimer plasma levels parallel the clinical response to omalizumab in patients with severe chronic spontaneous urticaria,” International Archives Allergy Immunology, vol. 172, no. 1, pp. 40–44, 2017. View at Publisher · View at Google Scholar
- W. Risau, “Mechanisms of angiogenesis,” Nature, vol. 386, no. 6626, pp. 671–674, 1997. View at Publisher · View at Google Scholar
- L. Folkman, “Angiogenesis in cancer, vascular, rheumatoid and other disease,” Nature Medicine, vol. 1, no. 1, pp. 27–31, 1995. View at Publisher · View at Google Scholar · View at Scopus
- D. W. Leung, G. Cachianes, W. J. Kuang, D. V. Goeddel, and N. Ferrara, “Vascular endothelial growth factor is a secreted angiogenic mitogen,” Science, vol. 246, no. 4935, pp. 1306–1309, 1989. View at Google Scholar
- A. Tedeschi, R. Asero, A. V. Marzano et al., “Plasma levels and skin-eosinophil-expression of vascular endothelial growth factor in patients with chronic urticaria,” Allergy, vol. 64, no. 11, pp. 1616–1622, 2009. View at Publisher · View at Google Scholar · View at Scopus
- I. Puxeddu, D. Ribatti, E. Crivellato, and F. Levi-Schaffer, “Mast cells and eosinophils: a novel link between inflammation and angiogenesis in allergic diseases,” Journal Allergy Clinical Immunology, vol. 116, no. 3, pp. 531–536, 2005. View at Publisher · View at Google Scholar · View at Scopus
- I. Puxeddu, S. C. Rabl, F. Panza et al., “Endostatin and thrombospondin-1 levels are increased in the sera of patients with chronic spontaneous urticaria,” Archives Dermatology Research, vol. 306, no. 2, pp. 197–200, 2014. View at Publisher · View at Google Scholar · View at Scopus
- J. S. Isenberg, L. A. Ridnour, J. Dimitry, W. A. Frazier, D. A. Wink, and D. D. Roberts, “CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1,” Journal Biological Chemistry, vol. 281, no. 36, pp. 26069–26080, 2006. View at Publisher · View at Google Scholar · View at Scopus
- D. Wenzel, A. Schmidt, K. Reimann et al., “Endostatin, the proteolytic fragment of collagen XVIII, induces vasorelaxation,” Circulation Research, vol. 98, no. 9, pp. 1203–1211, 2006. View at Publisher · View at Google Scholar · View at Scopus
- A. Tedeschi, R. Asero, M. Lorini, A. V. Marzano, and M. Cugno, “Plasma levels of matrix metalloproteinase-9 in chronic urticaria patients correlate with disease severity and C-reactive protein but not with circulating histamine-releasing factors,” Clinical Experimental Allergy, vol. 40, no. 6, pp. 875–881, 2010. View at Publisher · View at Google Scholar · View at Scopus
- F. Dilek, D. Ozceker, E. Ozkaya et al., “Plasma levels of matrix metalloproteinase-9 in children with chronic spontaneous urticaria,” Allergy Asthma Immunology Research, vol. 8, no. 6, pp. 522–526, 2016. View at Publisher · View at Google Scholar · View at Scopus
- A. Kessel, R. Bishara, A. Amital et al., “Increased plasma levels of matrix metalloproteinase-9 are associated with the severity of chronic urticaria,” Clinical Experimental Allergy, vol. 35, no. 2, pp. 221–225, 2005. View at Publisher · View at Google Scholar · View at Scopus
- S. Altrichter, N. Boodstein, and M. Maurer, “Matrix metalloproteinase-9: a novel biomarker for monitoring disease activity in patients with chronic urticaria patients?” Allergy, vol. 64, no. 4, pp. 652–656, 2009. View at Publisher · View at Google Scholar · View at Scopus