Expression and Function of Granzymes A and B in Escherichia coli Peritonitis and Sepsis

Figure 2

Granzyme A and B expression in NK cells from wild-type mice before and after intraperitoneal infection with E. coli. Mice were infected intraperitoneally with CFU E. coli and sacrificed before and at 6, 14, and 20 h after infection. Percentage and median fluorescence intensity (MFI) of intracellular gzmA (a, b) and gzmB (c, d) in NK cells from peritoneal lavage fluid (PLF) and blood are shown. Data are box-and-whisker diagrams depicting the smallest observation, lower quartile, median, upper quartile, and largest observation.  = 5-6 at each time point. , determined by Mann–Whitney U test.

(a)

(b)

(c)

(d)