Mediators of Inflammation / 2017 / Article / Fig 7

Research Article

Cannabinoid Receptor 2 Modulates Neutrophil Recruitment in a Murine Model of Endotoxemia

Figure 7

Proposed model for CB2 function in endotoxemia. During acute systemic inflammation CB2 suppresses neutrophil recruitment to the spleen. In the absence of this GPCR, the serum levels of the metalloproteinase MMP-9 are elevated and Ccl2, Ccl3, Cxcl10, and Il6 in the spleen are upregulated. As a result CB2 knockout, neutrophils follow the chemokine gradient and migrate to the spleen in higher numbers than in control littermate animals.