Research Article
Increased Abundance of Plasmacytoid Dendritic Cells and Interferon-Alpha Induces Plasma Cell Differentiation in Patients of IgA Nephropathy
Table 2
Association of pDC and IFN-alpha with clinical parameters and renal histopathology in IgAN patients.
| Feature | pDC percentage in PBMCs | IFN-alpha protein levels in plasma | Pearson’s r | value | Pearson’s r | value |
| Age (yr) | 0.05 | 0.76 | 0.15 | 0.39 | Serum creatinine (μM) | 0.027 | 0.88 | −0.09 | 0.58 | eGFR (ml/min per 1.73 m2) | 0.005 | 0.99 | −0.02 | 0.91 | 24-hour proteinuria (g/24 h) | 0.11 | 0.53 | 0.34 | 0.04 | Serum IgA (g/l) | −0.29 | 0.09 | 0.07 | 0.69 | Serum IgG (g/l) | 0.03 | 0.85 | 0.05 | 0.78 | Serum IgM (g/l) | 0.22 | 0.29 | 0.08 | 0.67 | Serum C3 (g/l) | 0.14 | 0.48 | −0.16 | 0.36 | CRP (mg/l) | 0.33 | 0.09 | −0.12 | 0.49 | SAA (mg/l) | 0.27 | 0.16 | −0.11 | 0.51 | ASO (Ku/l) | 0.31 | 0.11 | 0.22 | 0.20 | Anti-Dnase B (U/ml) | −0.21 | 0.28 | 0.48 | 0. 005 | Mesangail hypercellularity (M0/M1) | 0.09 | 0.62 | −0.07 | 0.69 | Endocapillary hypercellularity (E0/E1) | 0.04 | 0.84 | −0.06 | 0.63 | Tubular atrophy/ interstitial fibrosis (T0/T1/T2) | 0.03 | 0.89 | 0.37 | 0.03 | Segmental sclerosis (S0/S1) | 0.17 | 0.33 | 0.11 | 0.52 | Kidney IgA intensity | −0.23 | 0.20 | 0.03 | 0.85 | Kidney IgG intensity | 0.11 | 0.55 | −0.04 | 0.81 | Kidney IgM intensity | 0.45 | 0.009 | 0.34 | 0.04 | Kidney C3 intensity | −0.30 | 0.09 | 0.15 | 0.40 |
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C3: complement 3; CRP: C-reactive protein; SAA: serum amyloid A protein; ASO: antistreptolysin O. ; .
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