The Role of PDGFs and PDGFRs in Colorectal Cancer

Table 1

The role of PDGF/PDGFR families in colorectal carcinogenesis.

PDGF/PDGFR member	Role in CRC	References
PDGF-AB	Correlation with cancer grading	Mantur et al. [49]
	Early diagnosis and cancer grading	Yu et al. [48]
PDGF-BB	Increasing the pericytes within tumors and decreasing the tumor growth	McCarty et al. [54]
	Expression of this protein in CRC patients	Ito et al. [52]
	Correlation with tumor staging	Ionescu et al. [53]
	Biomarker for diagnosis	Belizon et al. [57]
PDGF-C	Metastatic disease	Yamauchi et al. [60]
	Early diagnosis	Manzat-Saplacan et al. [37]
PDGFR-α/β	Tumor angiogenesis, invasion, metastasis	Song et al. [38]
	Tumor angiogenesis, invasion, metastasis	Kitadai et al. [40]
	Correlation with advanced cancer	Erben et al. [47]
	Targeting PDGFRs as antiangiogenic therapy	Hurwitz et al. [62]
	Lymphatic dissemination/metastatic disease	Wehler et al. [46]
	Metastatic disease	Steller et al. [44]
	Poor survival	Estevez-Garcia et al. [45]