Characterization of the Proinflammatory Profile of Synovial Fluid-Derived Exosomes of Patients with Osteoarthritis

Figure 5

SF-derived exosomes stimulate the production of several MMPs by M1 macrophages. M1 macrophages were treated with SF-derived exosomes (a) or IFN-γ/LPS (b) for 24 h, and MMP production was determined in supernatants by the ELISA Bio-plex assay system. Data are expressed as fold change in relation to unstimulated cells. Columns, mean; bars, SD, significant difference from unstimulated cells .

(a)

(b)