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Mediators of Inflammation
Volume 2017, Article ID 5197592, 10 pages
Research Article

IL-10 and socs3 Are Predictive Biomarkers of Dengue Hemorrhagic Fever

1Centro de Investigación Biomédica de Oriente, HGZ5, Instituto Mexicano del Seguro Social, Km 4.5 Carretera Atlixco-Metepec, 74360 Metepec, PUE, Mexico
2Departamento de Ciencias Químico Biológicas y Agropecuarias, División de Ciencias e Ingeniería, Universidad de Sonora, 85880 Navojoa, SON, Mexico
3Departamento de Ciencias de la Salud, Universidad Popular Autónoma del Estado de Puebla, 21 Sur 1103, 72410 Puebla, PUE, Mexico
4Hospital General de Zona No. 5, Instituto Mexicano del Seguro Social, Km 4.5 Carretera Atlixco-Metepec, 74360 Metepec, PUE, Mexico
5Laboratorio de Bioquímica y Biología Molecular, Centro de Química, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Edif. 103 F, CU-BUAP, San Manuel, 72570 Puebla, PUE, Mexico

Correspondence should be addressed to Lilian Karem Flores-Mendoza; moc.liamg@meraknailil and Julio Reyes-Leyva; moc.oohay@avyelseyerj

Received 13 March 2017; Revised 3 June 2017; Accepted 27 June 2017; Published 30 July 2017

Academic Editor: Giuseppe Valacchi

Copyright © 2017 Lilian Karem Flores-Mendoza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Cytokines play important roles in the physiopathology of dengue infection; therefore, the suppressors of cytokine signaling (socs) that control the type and timing of cytokine functions could be involved in the origin of immune alterations in dengue. Objective. To explore the association of cytokine and socs levels with disease severity in dengue patients. Methods. Blood samples of 48 patients with confirmed dengue infection were analyzed. Amounts of interleukins IL-2, IL-4, IL-6, and IL-10, interferon- (IFN-) γ, and tumor necrosis factor- (TNF-) α were quantified by flow cytometry, and the relative expression of socs1 and socs3 mRNA was quantified by real-time RT-PCR. Results. Increased levels of IL-10 and socs3 and lower expression of socs1 were found in patients with dengue hemorrhagic fever (DHF) with respect to those with dengue fever (DF) (). Negative correlations were found between socs1 and both IL-10 and socs3 (). The cutoff values of socs3 (>199.8-fold), socs1 (<1.94-fold), and IL-10 (>134 pg/ml) have the highest sensitivity and specificity to discriminate between DF and DHF. Conclusion. Simultaneous changes in IL-10 and socs1/socs3 could be used as prognostic biomarkers of dengue severity.