IL-10 and socs3 Are Predictive Biomarkers of Dengue Hemorrhagic Fever
Table 1
Clinical characteristics of dengue patients during the outbreak of Puebla 2013.
All dengue patients
DF
DHF
values
Gender (masculine/feminine)
24/24
21/17
3/7
Mean age (range, years)
35.75 (12–59.5)
31 (12–58.5)
41 (12.5–62.5)
0.6938
Laboratory data
Hematocrit (%)
43.16 ± 7.22
44.8 ± 5.4
36.99 ± 9.94
0.0351
Hemoglobin (g/dl)
14.37 ± 2.48
14.94 ± 1.86
12.21 ± 3.38
0.0223
Platelet count (×104 cell/mm3)
5.41 ± 6.29&
5.8 ± 7
3.9 ± 2.3
0.7702
Albumin (U/ml)
3 ± 0.69&
3.23 ± 0.58
2.57 ± 0.65
0.0078
ALT (IU/ml)
80.05 ± 47.74&
65.73 ± 29.78
138 ± 15.3
0.0329
AST (IU/ml)
94.05 ± 59.75&
89.7 ± 54.77
165.6 ± 69.41
0.2179
White blood cells (×103 cell/mm3)
5.46 ± 2.86
5.63 ± 3.09
4.83 ± 1.59
0.6221
Lymphocytes (%)
34.91 ± 13.89
33.44 ± 13.76
40.2 ± 13.77
0.3634
Monocytes (%)
11.96 ± 6.15
12 ± 6.42
11.8 ± 5.37
0.9150
Neutrophils (%)
52.37 ± 17.41
53.61 ± 17.53
47.9 ± 17.07
0.3049
Clinical signs
Petechiae n (%)
19 (39.58)
12 (31.6)
7 (70)
0.0271
Epistaxis n (%)
10 (20.83)
5 (13.15)
5 (50)
0.0107
Gingival hemorrhage n (%)
7 (14.58)
3 (7.9)
4 (40)
0.0105
Hematoma n (%)
3 (6.25)
1 (2.63)
2 (20)
0.0435
Hematemesis n (%)
2 (4.16)
1 (2.63)
1 (10)
0.2995
Melena n (%)
2 (4.16)
1 (2.63)
1 (10)
0.2995
Data were obtained during the febrile period of the disease. Laboratory data express the average and standard deviation. Clinical data express the number of patients that presented the sign. values were determined by Mann–Whitney U test for continuous variables and by the χ2 test for categorical variables. & means significance with respect to reference values. , mean significance between DF and DHF.
