The Role of High-Mobility Group Box-1 and Its Crosstalk with Microbiome in Rheumatoid Arthritis

<div>A schematic representation of the interaction and the crosstalk between HMGB1 and gut microbiome in RA pathogenesis. Depending on the oxidation/reduction status after the passage through the gut microbiome, HMGB1 can play several and different roles in RA initiation and maintenance.</div>

Mediators of Inflammation

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Figure 1

Figure 1: The Role of High-Mobility Group Box-1 and Its Crosstalk with Microbiome in Rheumatoid Arthritis 