Specific Gene- and MicroRNA-Expression Pattern Contributes to the Epithelial to Mesenchymal Transition in a Rat Model of Experimental Colitis

Figure 2

Opposing expression of growth factors and their regulating miRNAs at the site of colon inflammation. The relative gene expression of growth factors Egr1 (a), Fgf2 (b), and Fgf7 (c) shows significant upregulation in inflamed colons as compared to both control and uninflamed colons of colitis-induced animals. In contrast, the expression pattern of both miR-192 (d) and miR-143 (e) shows slight upregulation in uninflamed colons and a significant downregulation in inflamed colons. Data are presented as the mean ± SEM; the significance of differences between sets of data was determined by one-way analysis of variance (ANOVA) using SPSS Statistics; .

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