Innate Immunity of Adipose Tissue in Rodent Models of Local and Systemic Staphylococcus aureus Infection

Figure 1

Natural course of fatal S. aureus endocarditis and serum adipokine concentrations in an experimental rat model. Serum and whole blood were collected from rats ( = 5–7 per time point) suffering from an ultimately fatal S. aureus endocarditis. Serum cytokine and adipokine levels were measured by ELISA in duplicate. (a) Cumulative survival of animals during the natural disease course. Cumulative survival is given in percent (%) during the time after infection given in hours (h). (b) Bacteremia during the natural disease course. Colony forming units are given in units/mL blood by using a logarithmic scale and were documented at day 1, day 2, and day 3 after infection. Bacteremia increased significantly (, one-way ANOVA) over time. (c) Time course of serum IL-6 concentrations in infected (black line) and noninfected control (spotted line) animals. IL-6 concentrations were increased in S. aureus infected rats; however, this trend did not reach significance (ns, not significant). (d) Time course of serum adiponectin concentrations in infected (black line) and noninfected control (spotted line) animals. Adiponectin concentrations were significantly (, two-way ANOVA) lower in rats with S. aureus endocarditis than in uninfected control animals. (e) Time course of serum visfatin concentrations in infected (black line) and noninfected control (spotted line) animals. Visfatin concentrations were significantly higher in S. aureus infected animals (, two-way ANOVA). (f) Time course of serum leptin concentrations in infected (black line) and noninfected control (spotted line) animals. Leptin concentrations were significantly higher in S. aureus infected animals (, two-way ANOVA).

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