Low Circulating TRAIL Levels Are Associated with Increase of Resistin and Lipocalin-2/ngal Adipokines in Postmenopausal Women

Table 2

Serum levels of adipokines and TRAIL according to abdominal obesity categories.

Parameters	Waist circumference (cm)
	≤79.9 []	80–87.9 []	≥88 []
IL-8 (pg/mL)	2.7 ± 0.9	3.3 ± 0.9	3.4 ± 1.9	NS
TNF-α (pg/mL)	1.7 (1.3–2.4)	1.9 (1.2–2.6)	2.0 (1.4–2.7)	NS
IL-6 (pg/mL)	0.4 (0.3–0.8)	0.5 (0.3–0.7)	1.0 (0.4–1.7)^a,b	<0.01
MCP-1 (pg/mL)	207 (147–306)	193 (158–276)	213 (166–278)	NS
Resistin (pg/mL)	11,051 ± 4628	13,398 ± 7721^a	13,540 ± 5476^a	<0.05
Adiponectin (μg/mL)	80 (49–170)	69 (37–158)^a	43 (22–57)^a,b	<0.01
HGF (pg/mL)	215 (108–318)	306 (187–483)	377 (272–571)^a,b	<0.01
NGF (pg/mL)	0.9 (0.7–1.2)	1.1 (0.9–1.5)	1.2 (0.8–1.6)	NS
Adipsin (μg/mL)	3.7 (3.1–4.5)	3.9 (3.3–4.8)	4.6 (4.8–6.0)^a,b	<0.01
Leptin (ng/mL)	6 (4–13)	14 (6–22)^a	29 (13–39)^a,b	<0.01
Lipocalin-2/ngal (ng/mL)	135 ± 48	157 ± 82	160 ± 60^a	<0.05
PAI-1 total (ng/mL)	46 ± 22	53 ± 22	61 ± 22^a	<0.01
TRAIL	100 ± 20	110 ± 23^a	110 ± 25	NS

Data presented are expressed as mean ± standard deviation for normal continuous variables; median (interquartile range) for nonnormal continuous variables. ANOVA (post hoc test: Tukey) or Kruskall-Wallis (post hoc test: Wilcoxon–Mann–Whitney test followed by Bonferroni correction). versus normal; versus overweight. IL: interleukin; PAI-1 total: plasminogen activator inhibitor-1; TNF-α: tumor necrosis factor alpha; MCP-1: monocyte chemoattractant protein; HGF: hepatocyte growth factor; ngal: neutrophil gelatinase-associated lipocalin; NGF: nerve growth factor.