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Mediators of Inflammation
Volume 2017, Article ID 5385102, 8 pages
Research Article

Suppressed Programmed Death 1 Expression on CD4+ and CD8+ T Cells in Psoriatic Patients

1Department of Dermatology, Venereology and Paediatric Dermatology, Medical University of Lublin, Lublin, Poland
2Experimental Hematooncology Department, Medical University of Lublin, Lublin, Poland
3Institute of Statistics and Demography, Warsaw School of Economics, Warsaw, Poland

Correspondence should be addressed to Joanna BartosiƄska; moc.liamg@iksnisotrabj

Received 13 May 2017; Accepted 6 August 2017; Published 17 October 2017

Academic Editor: Juarez A. S. Quaresma

Copyright © 2017 Joanna Bartosińska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Psoriasis is a chronic inflammatory disease mediated by T cell immunity. Programmed death 1 (PD-1), a coinhibitory receptor, plays an important role in immune regulation and maintaining peripheral tolerance. The aim of the study was to compare the expression of PD-1 on the peripheral T cells between psoriatic patients and healthy controls. The study included 75 psoriatic patients and 52 healthy volunteers. The percentages and absolute numbers of CD3+, CD4+, CD8+, CD4+PD-1+, and CD8+PD-1+ T cells were analyzed using flow cytometry. The absolute numbers and percentages of CD4+PD-1+ and CD8+PD-1+ T cells were significantly decreased in the psoriatic patients in comparison with the control group. No significant correlations were found between the absolute numbers and percentages of CD4+PD-1+ or CD8+PD-1+ T cells and clinical characteristics of psoriasis. Decreased PD-1 expression on the T cells may be responsible for impaired negative regulation of immune response in psoriasis pathogenesis.