Key Role of STAT4 Deficiency in the Hematopoietic Compartment in Insulin Resistance and Adipose Tissue Inflammation

Figure 1

Intraperitoneal glucose tolerance test (GTT) and insulin tolerance test (ITT) were performed after 15 weeks of HFD. For both the ITT and the GTT, STAT4−/− recipients that received STAT4+/+ bone marrow cells had significantly higher area under curve (AUC) compared to STAT4+/+ recipients that received STAT4−/− cells. Data represents average ± SD from 7 mice/group. The null hypothesis was rejected for a value < 0.05; .