Key Role of STAT4 Deficiency in the Hematopoietic Compartment in Insulin Resistance and Adipose Tissue Inflammation

Table 1

Body weight, plasma lipids, and glucose for STAT4-deficient or STAT4-sufficient mice following bone marrow transplant.

Phenotype	STAT4−/− recipient	STAT4+/+ recipient	value
Body weight (g)	31.7 ± 4.23	27.5 ± 3.87	NS
Total cholesterol (mg/dL)	188.71 ± 68.51	130.7 ± 35.5	NS
Free fatty acids (nmol/L)	0.66 ± 0.1	0.77 ± 0.18	NS
Triglycerides (mg/dL)	71.13 ± 10.85	62.13 ± 15.61	NS
Glucose (mg/dL)	150.25 ± 18.39	114.4 ± 19.15	<0.01

Results represent fasting body weights and plasma values at time of sacrifice. Data is from = 5–8 mice/group and represents mean ± SD. Statistical analysis was performed by unpaired Student’s -test and the null hypothesis was rejected for . STAT+/+ recipient represents mice with selective STAT4 deficiency in bone marrow cells (see Methods).