Adipokine Contribution to the Pathogenesis of Osteoarthritis

Figure 1

(a) Soluble mediators synthesized by white adipose tissue. Solid red arrows represent cytokines, growth factors, and hormones produced by obese white adipose tissue. Dotted red lines represent the inhibition of the soluble mediator expression by obese white adipose tissue. Solid green arrows depict endocrine and immune soluble mediators synthesized by lean white adipose tissue. Dotted green lines represent the inhibition of the soluble mediator expression by lean white adipose tissue. (b) Relationship of adipokines with the inflammation and the fat mass index in OA patients. sAdipokine: serum adipokine; BMI: body mass index.

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