Adipokine Contribution to the Pathogenesis of Osteoarthritis

Figure 5

Resistin signaling. Resistin is recognized by TLR4 receptor. Two signaling pathways are triggered through the recruitment of the adaptor molecules TIRAP and MyD88. The first through PI3K followed by Akt and NF-kB. The second through MAPK pathway, followed by upregulation of NF-kB.