Significant Improvement Selected Mediators of Inflammation in Phenotypes of Women with PCOS after Reduction and Low GI Diet
Table 1
Eicosanoid concentration before (PCOS-I), after (PCOS-II) the three-month dietary intervention, and the control group (CG).
Eicosanoids
PCOS-I
CG
value
Mean [μg/ml]
Mean [μg/ml]
6(R), 15(R)-lipoxin A4
0.26 ± 0.30
0.20 ± 0.16
NS
5(S), 6(R)-lipoxin A4
0.04 ± 0.10
0.05 ± 0.04
NS
16(R)/16(S)-HETE
0.03 ± 0.04
0.08 ± 0.04
13(S)-HODE
0.11 ± 0.08
0.21 ± 0.09
9(S)-HODE
0.15 ± 0.11
0.24 ± 0.11
15(S)-HETE
0.57 ± 0.45
1.01 ± 0.39
12(S)-HETE
1.00 ± 1.02
1.72 ± 0.61
5(S)-oxoETE
0.16 ± 0.20
0.47 ± 0.34
5(S)-HETE
0.29 ± 0.25
0.69 ± 0.29
Eicosanoids
HT
CG
value
Mean [μg/ml]
Mean [μg/ml]
6(R), 15(R)-lipoxin A4
0.27 ± 0.30
0.20 ± 0.15
NS
5(S), 6(R)-lipoxin A4
0.05 ± 0.13
0.05 ± 0.04
NS
16(R)/16(S)-HETE
0.03 ± 0.04
0.08 ± 0.04
13(S)-HODE
0.10 ± 0.08
0.21 ± 0.08
9(S)-HODE
0.15 ± 0.12
0.24 ± 0.10
15(S)-HETE
0.51 ± 0.37
1.01 ± 0.36
12(S)-HETE
0.85 ± 0.93
1.72 ± 0.57
NS
5(S)-oxoETE
0.13 ± 0.14
0.47 ± 0.31
5(S)-HETE
0.25 ± 0.22
0.69 ± 0.27
Eicosanoids
NT
CG
value
Mean [μg/ml]
Mean [μg/ml]
6(R), 15(R)-lipoxin A4
0.26 ± 0.29
0.20 ± 0.15
NS
5(S), 6(R)-Lipoxin A4
0.03 ± 0.03
0.05 ± 0.04
NS
16(R)/16(S)-HETE
0.04 ± 0.04
0.08 ± 0.04
13(S)-HODE
0.12 ± 0.08
0.21 ± 0.08
9(S)-HODE
0.15 ± 0.10
0.24 ± 0.10
15(S)-HETE
0.67 ± 0.54
1.01 ± 0.36
12(S)-HETE
1.24 ± 1.09
1.72 ± 0.57
5(S)-oxoETE
0.22 ± 0.26
0.47 ± 0.31
5(S)-HETE
0.35 ± 0.26
0.69 ± 0.27
Eicosanoids
HT
NT
value
Mean [μg/ml]
Mean [μg/ml]
6(R), 15(R)-lipoxin A4
0.27 ± 0.30
0.26 ± 0.29
NS
5(S), 6(R)-lipoxin A4
0.05 ± 0.13
0.03 ± 0.03
NS
16(R)/16(S)-HETE
0.03 ± 0.04
0.04 ± 0.04
NS
13(S)-HODE
0.10 ± 0.08
0.12 ± 0.08
NS
9(S)-HODE
0.15 ± 0.12
0.15 ± 0.10
NS
15(S)-HETE
0.51 ± 0.37
0.67 ± 0.54
NS
12(S)-HETE
0.85 ± 0.93
1.24 ± 1.09
NS
5(S)-oxoETE
0.13 ± 0.14
0.22 ± 0.26
NS
5(S)-HETE
0.25 ± 0.22
0.35 ± 0.26
NS
Eicosanoids
PCOS-I
PCOS-II
value
Mean [μg/ml]
Mean [μg/ml]
6(R), 15(R)-lipoxin A4
0.31 ± 0.31
0.23 ± 0.27
NS
5(S), 6(R)-lipoxin A4
0.03 ± 0.03
0.06 ± 0.08
NS
16(R)/16(S)-HETE
0.04 ± 0.03
0.06 ± 0.04
13(S)-HODE
0.13 ± 0.08
0.23 ± 0.08
9(S)-HODE
0.16 ± 0.09
0.26 ± 0.10
15(S)-HETE
0.75 ± 0.53
1.10 ± 0.46
12(S)-HETE
1.45 ± 1.05
2.28 ± 1.43
5(S)-oxoETE
0.25 ± 0.27
0.51 ± 0.34
5(S)-HETE
0.38 ± 0.24
0.68 ± 0.28
Eicosanoids
PCOS-II
CG
value
Mean [μg/ml]
Mean [μg/ml]
6(R), 15(R)-lipoxin A4
0.23 ± 0.27
0.20 ± 0.16
NS
5(S), 6(R)-lipoxin A4
0.06 ± 0.08
0.05 ± 0.04
NS
16(R)/16(S)-HETE
0.06 ± 0.04
0.08 ± 0.04
NS
13(S)-HODE
0.23 ± 0.08
0.21 ± 0.09
NS
9(S)-HODE
0.26 ± 0.10
0.24 ± 0.11
NS
15(S)-HETE
1.10 ± 0.46
1.01 ± 0.39
NS
12(S)-HETE
2.28 ± 1.43
1.72 ± 0.61
NS
5(S)-oxoETE
0.51 ± 0.34
0.47 ± 0.34
NS
5(S)-HETE
0.68 ± 0.28
0.69 ± 0.29
NS
Values are expressed as mean ± SD, . PCO-I: polycystic ovary syndrome, before dietetics intervention; PCO-II: polycystic ovary syndrome, after dietetics intervention; CG: control group; HT: high testosterone and/or high FAI; NT: normal levels of testosterone.
