Aloperine Protects Mice against DSS-Induced Colitis by PP2A-Mediated PI3K/Akt/mTOR Signaling Suppression

<div>Aloperine regulates PI3K/Akt/mTOR signaling <i>in vitro</i> and <i>in vivo</i>. (a) Western blotting analysis of PI3K/Akt/mTOR in Jurkat cells after 24 h treatment with 0.5 mM aloperine with or without different inhibitors (10 nM wortmannin (PI3K inhibitor), 4 <i>μ</i>M LB-100 (PP2A inhibitor), or 4 <i>μ</i>M perifosine (p-Akt inhibitor)). The data are shown as the mean ± SEM from three independent experiments. (b) Western blotting analysis of PI3K/Akt/mTOR in the mouse colon. (c) Western blotting analysis of protein phosphatase 2A (PP2A) in the mouse colon. 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Mediators of Inflammation

fig5

Figure 5

Figure 5: Aloperine Protects Mice against DSS-Induced Colitis by PP2A-Mediated PI3K/Akt/mTOR Signaling Suppression 