Aloperine Protects Mice against DSS-Induced Colitis by PP2A-Mediated PI3K/Akt/mTOR Signaling Suppression

Figure 6

PP2A is involved in the aloperine-induced suppression of PI3K/Akt/mTOR signaling. (a) Western blotting analysis of total and phosphorylated PI3K/Akt/mTOR in conventional and activated T-cell after 24 h treatment with aloperine (0.25 mM) and LB-100 (4 μM). (b) Western blotting analysis of total and phosphorylated PI3K/Akt/mTOR in activated and nonactivated human splenic mononuclear cells after 24 h treatment with aloperine (0.25 mM) and LB-100 (4 μM). The data are shown as the mean ± SEM from three independent experiments. , , and . ns: not significant.

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