Association Study of Tumor Necrosis Factor Receptor 1 (TNFR1) Gene Polymorphisms with Schizophrenia in the Polish Population

Table 1

Genotype and allele distributions for the TNFR1 (rs4149576, rs4149577, and rs1860545) polymorphisms in paranoid schizophrenia patients () and control subjects ().

Polymorphisms	N (%)
	Genotype					Allele
rs4149576	T/T	C/T	C/C	χ^2	p	T	C	χ^2	p
Patients	108 (28)	190 (49)	90 (23)	0.34	0.84	406 (52)	370 (48)	0.35	0.55
Control	174 (26)	322 (49)	161 (25)			670 (51)	644 (49)
Male patients	64 (27)	114 (48)	59 (25)	0.68	0.71	242 (51)	232 (49)	0.34	0.55
Male controls	82 (24)	172 (50)	88 (26)			336 (49)	348 (51)
Female patients	44 (29)	76 (50)	31 (21)	0.47	0.78	164 (54)	138 (46)	0.08	0.76
Female controls	92 (29)	150 (48)	73 (23)			334 (53)	296 (47)
rs4149577	A/A	A/G	G/G	χ^2	p	A	G	χ^2	p
Patients	122 (31)	201 (52)	65 (17)	3.07	0.21	445 (57)	331 (43)	0.02	0.88
Control	222 (33)	305 (46)	130 (19)			749 (57)	565 (43)
Male patients	72 (30)	121 (51)	44 (19)	0.40	0.81	265 (56)	209 (44)	0.04	0.83
Male controls	105 (31)	167 (49)	70 (20)			377 (55)	307 (45)
Female patients	50 (33)	80 (53)	21 (14)	3.8	0.14	180 (60)	122 (40)	0.03	0.88
Female controls	117 (37)	138 (44)	60 (19)			372 (59)	258 (41)
rs1860545	G/G	G/A	A/A	χ^2	p	A	G	χ^2	p
Patients	96 (25)	193 (50)	99 (26)	0.79	0.67	391 (50)	385 (50)	0.69	0.41
Control	174 (26)	330 (51)	153 (23)			636 (48)	678 (52)
Male patients	62 (26)	115 (49)	60 (25)	0.91	0.63	235 (50)	239 (50)	0.60	0.43
Male controls	95 (28)	172 (50)	75 (22)			322 (47)	362 (53)
Female patients	34 (23)	78 (52)	39 (26)	0.36	0.83	156 (52)	146 (48)	0.20	0.65
Female controls	79 (25)	158 (50)	78 (25)			314 (50)	316 (50)