Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation

<div>S1PR4 signaling. S1PR4 couples to G<i>α</i><sub>i</sub> and G<i>α</i><sub>12/13</sub> to regulate cell survival, actin dynamics, and receptor trafficking. G<i>α</i><sub>i</sub> activation downstream of S1PR4 mediates cytosolic Ca<sup>2+</sup> increases via PLC and directly or indirectly induces ERK1/2 and Src signaling. G<i>α</i><sub>12/13</sub> predominantly triggers RhoA and subsequent ROCK activity. Cell type-specific signaling events are indicated. Details can be found in the main text. ERK: extracellular-signal regulated kinase; HER2: human epidermal growth factor receptor 2; ILT7: immunoglobulin-like transcript 7; NGF: nerve growth factor; PLC: phospholipase C; PTEN: phosphatase and tensin homolog; RhoGEF: Rho guanine nucleotide exchange factor; ROCK: RhoA kinase; TRKA: tropomyosin receptor kinase A.</div>

Mediators of Inflammation

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Figure 1: Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation 

Figure 1 | Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation 