MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression

Figure 6

IL-17 and MBD2 expression under IRF4 gene silencing (I(−)) or overexpression (I(+)). Under I(−), IL-17 and IRF4 protein expression were significantly lower than that of the empty transfection group (I(0)) according to Western blot analyses; under I(+), IL-17 and IRF4 protein expression were markedly increased compared to that of I(0). Under I(−) or I(+), MBD2 protein expression showed no significant difference.