5-HT Drives Mortality in Sepsis Induced by Cecal Ligation and Puncture in Mice

Figure 1

5-HT drives the survival rate in a sepsis and septic shock model in mice. Kaplan-Meier survival curve for mice 5 days after the CLP sepsis model and 3 days after the CLP septic shock model. PCPA, a TPH1-inhibitor, at a dose of 150 mg/kg/day for 3 days by subcutaneous injection before the CLP. 5-Hydroxytryptophan (5-HTP), a precursor of 5-HT that can reload the 5-HT content, at a dose of 75 mg/kg/day for 3 days by subcutaneous injection before CLP). (WT sham group and KO sham group, ; WT-CLP groups, KO-CLP groups, WT+PCPA-CLP groups or KO+HTP-CLP groups, , was statistically significant.)