5-HT Drives Mortality in Sepsis Induced by Cecal Ligation and Puncture in Mice

Figure 11

Lack of 5-HT decreases the level of MPO in the lung in CLP-induced sepsis. MPO staining of the lung tissue at 24 h after CLP administration. The MPO-stained cells (green), the corresponding nuclear counterstaining (blue), and both channels merged display the relative change in the level of MPO observed in a typical field. The MPO staining was significantly decreased in the KO-CLP sepsis group compared to the WT-CLP sepsis group in the lung at 24 h after CLP. Original magnifications, ×400.